Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721644 | 0.91 | GPR119 (0.46) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL4718826 | 0.91 | GPR119 (0.40) | S1PR1GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL389178 | 0.90 | CYP3A4 (0.48) | GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL4720626 | 0.89 | S1PR1 (0.42) | S1PR1GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL4719875 | 0.88 | MKNK1 (0.39) | GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL4723185 | 0.87 | TBK1 (0.38) | GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL4724030 | 0.86 | KDR (0.39) | TBK1 | |
| SCHEMBL4721977 | 0.85 | GPR119 (0.43) | GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL4718652 | 0.85 | TBK1 (0.39) | GPR119CYP3A4CYP2C9TBK1 | |
| SCHEMBL4723218 | 0.85 | GPR119 (0.46) | GPR119CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |