Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.39 |
| ▸ | EGFR | P00533 | 15/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 5/20 | 0.38 |
| ▸ | FLT4 | P35916 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | TEK | Q02763 | 2/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719875 | 0.93 | MKNK1 (0.39) | KDRHTR2ASLC6A4MKNK1TBK1 | |
| SCHEMBL4723185 | 0.91 | TBK1 (0.38) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4720580 | 0.91 | TBK1 (0.37) | KDREGFRABL1ERBB2EPHA2 | |
| SCHEMBL4718652 | 0.90 | TBK1 (0.39) | ABL1LCKBCRFGFR4PTK6 | |
| SCHEMBL386381 | 0.89 | GPR119 (0.46) | KDREGFRTBK1 | |
| SCHEMBL4720573 | 0.89 | GPR119 (0.48) | IRAK4TBK1 | |
| SCHEMBL4721644 | 0.89 | GPR119 (0.46) | — | |
| SCHEMBL4763290 | 0.87 | TBK1 (0.40) | LCKHTR2ASLC6A4MKNK1TBK1 | |
| SCHEMBL4724082 | 0.87 | TBK1 (0.38) | KDRABL1LCKFGFR4PTK6 | |
| SCHEMBL4722370 | 0.86 | TBK1 (0.39) | FGFR1FGFR4HTR2ASLC6A4TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |