Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719875 | 0.94 | MKNK1 (0.39) | TBK1KDRGPR119ACACBMKNK1 | |
| SCHEMBL4724030 | 0.91 | KDR (0.39) | TBK1KDREGFRFGFR1FLT1 | |
| SCHEMBL4718652 | 0.90 | TBK1 (0.39) | TBK1GPR119ACACBCYP3A4CYP2C9 | |
| SCHEMBL4721644 | 0.89 | GPR119 (0.46) | GPR119CYP3A4CYP2C9 | |
| SCHEMBL4720573 | 0.89 | GPR119 (0.48) | TBK1GPR119 | |
| SCHEMBL386784 | 0.89 | GPR119 (0.46) | TBK1GPR119MKNK1CYP3A4CYP2C9 | |
| SCHEMBL4720580 | 0.88 | TBK1 (0.37) | TBK1KDREGFRGPR119ACACB | |
| SCHEMBL4763290 | 0.88 | TBK1 (0.40) | TBK1GPR119ACACBMKNK1 | |
| SCHEMBL4724082 | 0.87 | TBK1 (0.38) | TBK1KDRGPR119ACACBABL1 | |
| SCHEMBL4722370 | 0.87 | TBK1 (0.39) | TBK1FGFR1GPR119ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |