Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24672240 | 1.00 | HIF1A (0.35) | HIF1AMAPTPDE4AKDRCA2 | |
| SCHEMBL12671511 | 0.97 | CA2 (0.35) | CA2CA12CA1CA9SIGMAR1 | |
| SCHEMBL8467 | 0.97 | — | — | |
| SCHEMBL930605 | 0.97 | — | — | |
| SCHEMBL10578128 | 0.97 | CA2 (0.35) | CA2CA12CA1CA9SIGMAR1 | |
| Hydrochloric Acid SCHEMBL1739117 | 0.94 | — | — | |
| SCHEMBL16667767 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL17560377 | 0.94 | CA2 (0.33) | CA2CA12CA1CA9SIGMAR1 | |
| SCHEMBL1678682 | 0.94 | CA2 (0.37) | CA2CA12CA1CA9SIGMAR1 | |
| SCHEMBL3881127 | 0.94 | CA2 (0.33) | CA2CA12CA1CA9SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988305-A1 | A PROCESS FOR THE PREPARATION OF 5H,9bH-2a, 4a,7,9a-OCTAHYDROTETRAAZACYCLOOCTA cd]PENTALENE | BRACCO INTERNATIONAL B.V. (NL) | 2000-03-29 | — | — | EP | claimed |
| WO-1998056791-A1 | A PROCESS FOR THE PREPARATION OF 5H,9bH-2a, 4a,7,9a-OCTAHYDROTETRAAZACYCLOOCTA [cd]PENTALENE | BRACCO S.P.A. (IT) | 1998-12-17 | — | — | WO | claimed |
| US-5674470-A | Method for imaging mammalian tissue using 1-substituted- 4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs | BRACCO DIAGNOSTICS INC. (US) | 1997-10-07 | — | — | US | claimed |
| US-11905257-B2 | Manufacturing process for preparing gadoteridol | BRACCO IMAGING S.P.A. (IT) | 2024-02-20 | — | — | US | disclosed |
| US-20230391735-A1 | MANUFACTURING PROCESS FOR PREPARING GADOTERIDOL | BRACCO IMAGING S.P.A. (IT) | 2023-12-07 | — | — | US | disclosed |
| EP-3442949-B1 | CONTRAST AGENTS | BRACCO IMAGING SPA (IT) | 2022-06-08 | — | — | EP | disclosed |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2022-05-10 | — | — | US | disclosed |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2022-05-10 | — | — | US | disclosed |
| US-11007283-B2 | Contrast agents | BRACCO IMAGING S.P.A. (IT) | 2021-05-18 | — | — | US | disclosed |
| CN-108084105-B | Gadoteridol intermediate, synthetic method thereof and method for preparing gadoteridol by using gadoteridol intermediate | 四川科伦药物研究院有限公司 | 2020-07-24 | — | — | CN | disclosed |
| US-20190167819-A1 | CONTRAST AGENTS | BRACCO IMAGING S.P.A. (IT) | 2019-06-06 | — | — | US | disclosed |
| US-5573752-A | Aromatic amide compounds and metal chelates thereof | BRACCO INTERNATIONAL B.V. | 1996-11-12 | — | — | US | disclosed |
| EP-0292689-B1 | Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs | BRACCO INT BV (NL) | 1996-07-31 | — | — | EP | disclosed |
| EP-0700392-A1 | USE OF MACROCYCLIC METAL COMPLEXES AS TEMPERATURE PROBES | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5474756-A | Chelate compound of a paramagnetic ion of lanthanide element | BRACCO INTERNATIONAL B.V. (NL) | 1995-12-12 | — | — | US | disclosed |
| WO-1995027705-A1 | AROMATIC AMIDE COMPOUNDS AND METAL CHELATES THEREOF | BRACCO INTERNATIONAL B.V. (NL) | 1995-10-19 | — | — | WO | disclosed |
| WO-1994027977-A1 | USE OF MACROCYCLIC METAL COMPLEXES AS TEMPERATURE PROBES | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-12-08 | — | — | WO | disclosed |
| EP-0543482-A1 | Aminocarboxylate ligands having substituted aromatic amide moieties | BRACCO INTERNATIONAL B.V. (NL) | 1993-05-26 | — | — | EP | disclosed |
| US-4885363-A | RADIOPHARMACEUTICAL IMAGING; MEDICAL DIAGNOSIS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0292689-A2 | Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs | BRACCO INTERNATIONAL B.V. (NL) | 1988-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11007283-B2 | Contrast agents | PHOSPHO1, ITPA, PPIP5K2 | HIF1A 952/4885MAPT 3772/4885PDE4A 1606/4885 |
| US-20230391735-A1 | MANUFACTURING PROCESS FOR PREPARING GADOTERIDOL | SSTR2, GCG, ADCYAP1R1 | HIF1A 813/4885MAPT 4006/4885PDE4A 721/4885 |
| US-20190167819-A1 | CONTRAST AGENTS | PHOSPHO1, ITPA, PPIP5K2 | HIF1A 952/4885MAPT 3772/4885PDE4A 1606/4885 |
| US-11905257-B2 | Manufacturing process for preparing gadoteridol | SSTR2, GCG, ADCYAP1R1 | HIF1A 813/4885MAPT 4006/4885PDE4A 721/4885 |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | HDGF, F11, F12 | HIF1A 1255/4885MAPT 4184/4885PDE4A 4798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.