Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247543 | 0.91 | MEN1 (0.58) | MEN1KMT2AMAPK1TSHRLMNA | |
| SCHEMBL4722493 | 0.87 | SMN1; SMN2 (0.54) | MEN1KMT2AMAPK1TSHRLMNA | |
| SCHEMBL8246614 | 0.82 | ALDH1A1 (0.62) | KMT2ATSHRLMNAHTTALDH1A1 | |
| SCHEMBL8250360 | 0.81 | MAPK1 (0.47) | MEN1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL8250559 | 0.81 | SLC6A7 (0.51) | MEN1KMT2AMAPK1TSHRHTT | |
| SCHEMBL4719711 | 0.81 | KMT2A (0.73) | MEN1KMT2AMAPK1TSHRLMNA | |
| SCHEMBL4718989 | 0.80 | ALDH1A1 (0.53) | MEN1KMT2AMAPK1TSHRLMNA | |
| SCHEMBL8247070 | 0.79 | SMN1; SMN2 (0.72) | MEN1KMT2AMAPK1TSHRLMNA | |
| SCHEMBL4761009 | 0.79 | MEN1 (0.56) | MEN1KMT2AMAPK1TSHRLMNA | |
| SCHEMBL4719103 | 0.79 | ABL1 (0.55) | MAPK1TSHRLMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907363-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | Bayer HealthCare AG (DE) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |