Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4813858 | 0.98 | SORD (0.52) | SORDAKT1ROCK1GPR119RIPK1 | |
| SCHEMBL9371315 | 0.85 | AKT1 (0.55) | SORDAKT1ROCK1GPR119LSS | |
| SCHEMBL9767811 | 0.84 | — | — | |
| SCHEMBL9558128 | 0.79 | SORD (0.55) | SORDAKT1ROCK1GPR119RIPK1 | |
| SCHEMBL14344836 | 0.79 | SORD (0.52) | SORDAKT1ROCK1GPR119RIPK1 | |
| SCHEMBL1459007 | 0.78 | ALDH1A1 (0.68) | ALDH1A1KDM4ECYP3A4CYP2C9HPGD | |
| SCHEMBL6181710 | 0.78 | RIPK1 (0.58) | SORDAKT1GPR119RIPK1LSS | |
| Hydrochloric Acid SCHEMBL1990072 | 0.76 | RIPK1 (0.57) | SORDAKT1GPR119RIPK1LSS | |
| SCHEMBL4453478 | 0.76 | SORD (0.56) | SORDAKT1ROCK1GPR119RIPK1 | |
| SCHEMBL30775404 | 0.76 | SORD (0.56) | SORDAKT1ROCK1GPR119RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100448875-C | Substituted 1-piperazinoylpiperidine derivatives, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2009-01-07 | — | — | CN | disclosed |
| EP-1513835-B1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2006-08-16 | — | — | EP | disclosed |
| CN-1675203-A | Substituted 1-piperazinoylpiperidine derivatives, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2005-09-28 | — | — | CN | disclosed |
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |
| CN-1228087-A | Substituted pyrimidine derivatives and their pharmaceutical use | ZENECA LTD (GB) | 1999-09-08 | — | — | CN | disclosed |