Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.60 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720647 | 0.91 | KEAP1 (0.55) | KEAP1NFE2L2MAPTGFERMEN1 | |
| SCHEMBL4722720 | 0.89 | KEAP1 (0.49) | KEAP1NFE2L2MAPTGFERMEN1 | |
| SCHEMBL4724761 | 0.88 | KEAP1 (0.56) | KEAP1NFE2L2MAPTGFERMEN1 | |
| SCHEMBL4722682 | 0.87 | KEAP1 (0.59) | KEAP1NFE2L2MAPTGFERNPC1 | |
| SCHEMBL4720269 | 0.85 | KEAP1 (0.48) | KEAP1NFE2L2MAPTNPC1RAB9A | |
| SCHEMBL4722007 | 0.82 | KEAP1 (0.50) | KEAP1NFE2L2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4721008 | 0.81 | MAPT (0.49) | KEAP1NFE2L2MAPTMEN1KMT2A | |
| SCHEMBL4720939 | 0.77 | MAPT (0.51) | KEAP1NFE2L2MAPTMEN1KMT2A | |
| SCHEMBL4721400 | 0.77 | KEAP1 (0.44) | KEAP1NFE2L2MAPTMEN1KMT2A | |
| SCHEMBL13635446 | 0.76 | CA1 (0.54) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | claimed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |