Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.38 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.37 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104386 | 0.82 | CENPE (0.42) | CENPEKIFC1WDR5S1PR1P2RX3 | |
| SCHEMBL5569230 | 0.81 | CENPE (0.37) | CENPEKIFC1WDR5S1PR1P2RX3 | |
| SCHEMBL2630625 | 0.77 | CENPE (0.41) | CENPEKIFC1WDR5S1PR1P2RX3 | |
| SCHEMBL4835978 | 0.75 | CENPE (0.44) | CENPEFOXO1KIFC1TOP2AWDR5 | |
| SCHEMBL2105714 | 0.74 | KIFC1 (0.38) | CENPEKIFC1WDR5S1PR1S1PR3 | |
| SCHEMBL4880118 | 0.73 | S1PR1 (0.37) | CENPEFOXO1KIFC1TOP2AS1PR1 | |
| SCHEMBL2104482 | 0.71 | HPSE (0.46) | FOXO1 | |
| SCHEMBL4876587 | 0.70 | S1PR1 (0.39) | CENPES1PR1S1PR3S1PR5P2RX3 | |
| SCHEMBL4777470 | 0.70 | S1PR1 (0.38) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL2104984 | 0.69 | CENPE (0.41) | CENPEKIFC1S1PR1P2RX3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |