Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | CENPE | Q02224 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777470 | 0.86 | S1PR1 (0.38) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL4777738 | 0.83 | S1PR1 (0.36) | S1PR1S1PR3S1PR5MAP4K4MINK1 | |
| SCHEMBL4792889 | 0.79 | CENPE (0.39) | S1PR1S1PR3S1PR5CENPEMAP4K4 | |
| SCHEMBL4882162 | 0.79 | CENPE (0.39) | S1PR1S1PR3S1PR5CENPEMAP4K4 | |
| SCHEMBL4876587 | 0.77 | S1PR1 (0.39) | S1PR1S1PR3S1PR5CENPEMAP4K4 | |
| SCHEMBL4835978 | 0.76 | CENPE (0.44) | S1PR1S1PR3S1PR5CENPEKIFC1 | |
| SCHEMBL4722945 | 0.73 | CENPE (0.38) | S1PR1S1PR3S1PR5CENPEMAP4K4 | |
| SCHEMBL14031435 | 0.70 | DHODH (0.43) | S1PR1S1PR3S1PR5CENPEMAP4K4 | |
| SCHEMBL4720739 | 0.70 | CENPE (0.45) | S1PR1S1PR3S1PR5CENPEMAP4K4 | |
| SCHEMBL3462824 | 0.69 | CENPE (0.47) | S1PR1S1PR3S1PR5CENPEMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942732-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056143-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |