Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14101965 | 0.93 | GAA (0.41) | MAOBDHODHBRD4THRBMEN1 | |
| SCHEMBL646805 | 0.79 | ALDH1A1 (0.51) | MAOBDHODHBRD4THRBMEN1 | |
| SCHEMBL4723735 | 0.75 | DHODH (0.47) | MAOBDHODHTHRBMEN1KMT2A | |
| SCHEMBL14101967 | 0.73 | MEN1 (0.36) | MAOBMEN1KMT2AGAAKDM4E | |
| SCHEMBL12772157 | 0.73 | KMT2A (0.60) | MAOBTHRBMEN1KMT2AGAA | |
| SCHEMBL25201648 | 0.69 | MAOB (0.45) | MAOBDHODHTHRBGAAMAPT | |
| SCHEMBL31500322 | 0.69 | MAPT (0.50) | MAOBTHRBMEN1KMT2AGAA | |
| SCHEMBL23906959 | 0.69 | MAOB (0.79) | MAOBMEN1KMT2AGAAMAPT | |
| SCHEMBL13508905 | 0.68 | MAPT (0.45) | MAOBTHRBMEN1KMT2AGAA | |
| SCHEMBL7743406 | 0.68 | MAOB (0.67) | MAOBMEN1KMT2AAPPABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |