Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 6/20 | 0.43 |
| ▸ | RXRA | P19793 | 6/20 | 0.43 |
| ▸ | RXRG | P48443 | 4/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31310458 | 0.91 | THRB (0.42) | MAOBMAOADHODHTHRATHRB | |
| SCHEMBL21806587 | 0.83 | MAOA (0.46) | MAOBMAOARXRBRXRARXRG | |
| SCHEMBL22802353 | 0.79 | RXRB (0.49) | MAOBMAOARXRBRXRARXRG | |
| SCHEMBL646805 | 0.78 | ALDH1A1 (0.51) | MAOBDHODHRXRBRXRARXRG | |
| SCHEMBL4723735 | 0.77 | DHODH (0.47) | MAOBMAOADHODHTHRATHRB | |
| SCHEMBL3289929 | 0.76 | MAOB (0.40) | MAOBMAOARXRBRXRARXRG | |
| SCHEMBL31359535 | 0.74 | MAOB (0.39) | MAOBMAOADHODHRXRBRXRA | |
| SCHEMBL25194199 | 0.74 | MAOB (0.48) | MAOBMAOADHODHTHRATHRB | |
| SCHEMBL23870190 | 0.73 | CXCR2 (0.52) | MAOBRXRBRXRARXRGMRGPRX4 | |
| SCHEMBL23858971 | 0.73 | RXRB (0.41) | MAOBMAOARXRBRXRARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12617802-B2 | Sulfonimidamide compounds as NLRP3 modulators | GENENTECH, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-20240336625-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2024-10-10 | — | — | US | disclosed |
| CN-116063163-B | Preparation method of 7- (benzyloxy) -2,4,5, 6-tetrahydro-1H-cyclobutadiene [ f ] indene-1-one | 上海毕臣生化科技有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-116063163-B | Preparation method of 7- (benzyloxy) -2,4,5, 6-tetrahydro-1H-cyclobutadiene [ f ] indene-1-one | 上海毕臣生化科技有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-117677622-A | Sulfonyl imide amide compounds and uses thereof | 基因泰克公司 | 2024-03-08 | — | — | CN | disclosed |
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | GENENTECH, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | GENENTECH, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| CN-116063163-A | Preparation method of 7- (benzyloxy) -2,4,5, 6-tetrahydro-1H-cyclobutadiene [ f ] indene-1-one | 上海毕臣生化科技有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-116063163-A | Preparation method of 7- (benzyloxy) -2,4,5, 6-tetrahydro-1H-cyclobutadiene [ f ] indene-1-one | 上海毕臣生化科技有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115461120-A | Sulfonylimide compounds as NLRP3 modulators | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |
| EP-4093509-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | NLRP3, NLRP1, PYCARD | MAOB 2568/4885MAOA 3087/4885DHODH 2189/4885 |
| US-12617802-B2 | Sulfonimidamide compounds as NLRP3 modulators | NLRP3, NLRP1, PYCARD | MAOB 3430/4885MAOA 3324/4885DHODH 3419/4885 |
| US-20240336625-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | NLRP3, PYCARD, NLRP1 | MAOB 2844/4885MAOA 2959/4885DHODH 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.