Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719266 | 0.81 | LRRK2 (0.33) | CRHR1LRRK2 | |
| SCHEMBL4719047 | 0.78 | ITGB2 (0.40) | — | |
| SCHEMBL4719042 | 0.78 | ITGB2 (0.40) | — | |
| SCHEMBL4722849 | 0.77 | BRD4 (0.45) | — | |
| SCHEMBL4722066 | 0.76 | — | — | |
| SCHEMBL14101952 | 0.76 | AKR1B10 (0.32) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4720890 | 0.76 | EGFR (0.33) | — | |
| SCHEMBL4720875 | 0.75 | BRD4 (0.37) | — | |
| SCHEMBL4721608 | 0.73 | AKR1B10 (0.33) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4719016 | 0.71 | AKR1B10 (0.33) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |