Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 3/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721330 | 0.90 | SYK (0.39) | TBK1GPR119ACACBSYK | |
| SCHEMBL4719875 | 0.89 | MKNK1 (0.39) | TBK1GPR119ACACB | |
| SCHEMBL389695 | 0.88 | GPR119 (0.47) | TBK1GPR119JAK2JAK1SLC34A1 | |
| SCHEMBL4763290 | 0.88 | TBK1 (0.40) | TBK1GPR119ACACBCACNA1H | |
| SCHEMBL4719368 | 0.87 | TBK1 (0.38) | TBK1GPR119ACACBJAK2SYK | |
| SCHEMBL4723287 | 0.86 | TBK1 (0.39) | TBK1GPR119ACACBCACNA1H | |
| SCHEMBL4719783 | 0.85 | TBK1 (0.39) | TBK1GPR119ACACBJAK2JAK1 | |
| SCHEMBL4718652 | 0.85 | TBK1 (0.39) | TBK1GPR119ACACBCACNA1H | |
| SCHEMBL4722370 | 0.85 | TBK1 (0.39) | TBK1GPR119ACACBCACNA1H | |
| SCHEMBL4723185 | 0.84 | TBK1 (0.38) | TBK1GPR119ACACBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |