Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763290 | 0.91 | TBK1 (0.40) | TBK1ACACBGPR119CACNA1HHTR2A | |
| SCHEMBL4724082 | 0.90 | TBK1 (0.38) | TBK1ACACBGPR119CACNA1HFGFR4 | |
| SCHEMBL4719875 | 0.90 | MKNK1 (0.39) | TBK1ACACBGPR119HTR2AHTR2C | |
| SCHEMBL389867 | 0.89 | TBK1 (0.46) | TBK1GPR119 | |
| SCHEMBL4718652 | 0.89 | TBK1 (0.39) | TBK1ACACBGPR119CACNA1HFGFR4 | |
| SCHEMBL4720580 | 0.88 | TBK1 (0.37) | TBK1ACACBGPR119CACNA1H | |
| SCHEMBL4723185 | 0.87 | TBK1 (0.38) | TBK1ACACBGPR119FGFR1 | |
| SCHEMBL4724030 | 0.86 | KDR (0.39) | TBK1FGFR1FGFR4HTR2ASLC6A4 | |
| SCHEMBL4723287 | 0.86 | TBK1 (0.39) | TBK1ACACBGPR119CACNA1HFGFR4 | |
| SCHEMBL4722378 | 0.86 | TBK1 (0.37) | TBK1ACACBGPR119CACNA1HCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |