Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 5/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CBR1 | P16152 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416209 | 0.79 | TTR (0.58) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL2058923 | 0.78 | TTR (0.53) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL28824294 | 0.77 | KCNH2 (0.46) | — | |
| SCHEMBL29707595 | 0.77 | KCNH2 (0.46) | — | |
| Soneclosan SCHEMBL29359126 | 0.75 | TTR (0.66) | TTRNR1I2LMNAPGRHSP90AA1 | |
| Soneclosan SCHEMBL465591 | 0.75 | TTR (0.66) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL10540653 | 0.74 | TTR (0.83) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL4586762 | 0.73 | TTR (0.63) | TTRNR1I2LMNAPGRHSP90AA1 | |
| SCHEMBL23087217 | 0.73 | XDH (0.49) | LMNA | |
| SCHEMBL23087679 | 0.73 | CHRNB2 (0.44) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912935-A2 | HIV REVERSE TRANSCRIPTASE INHIBITORS | Merck & Co., Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015809-A2 | HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | disclosed |