Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720063 | 0.93 | UTS2R (0.35) | AGTR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4722714 | 0.92 | KCNA5 (0.33) | AGTR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4724165 | 0.89 | UTS2R (0.37) | MEN1KMT2AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2067322 | 0.86 | TAAR1 (0.34) | MAPTL3MBTL1 | |
| SCHEMBL4722599 | 0.82 | CSNK1D (0.33) | KCNA5KCNH2SMN1; SMN2CYP2D6KCNE1 | |
| SCHEMBL4722931 | 0.82 | MAPT (0.38) | MAPTL3MBTL1LMNA | |
| SCHEMBL20184783 | 0.76 | TP53 (0.34) | HCAR3DRD2DRD3 | |
| SCHEMBL2068626 | 0.76 | CHRNB2 (0.35) | — | |
| SCHEMBL4722782 | 0.76 | KDM4E (0.38) | MAPTL3MBTL1SLC6A2 | |
| SCHEMBL4724413 | 0.74 | MAPT (0.32) | AGTR1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2514402-B1 | PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION | POLA CHEM IND INC (JP) | 2016-08-31 | — | — | EP | disclosed |
| US-9414998-B2 | Preventing or ameliorating agent for pigmentation | POLA CHEMICAL INDUSTRIES INC. (JP) | 2016-08-16 | — | — | US | disclosed |
| US-20140322150-A1 | PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION | POLA CHEMICAL INDUSTRIES INC. (JP) | 2014-10-30 | — | — | US | disclosed |
| EP-2514402-A1 | PROPHYLACTIC OR AMELIORATING AGENT FO PIGMENTATION | Pola Chemical Industries Inc. (JP) | 2012-10-24 | — | — | EP | disclosed |
| US-20120258063-A1 | PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION | POLA CHEMICAL INDUSTRIES INC. (JP) | 2012-10-11 | — | — | US | disclosed |
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFIZER INC. | 2008-07-24 | — | — | US | disclosed |
| EP-1874780-A1 | 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | TBXA2R, P2RY4, PF4 | AGTR1 507/4885MEN1 4451/4885NPC1 3867/4885 |
| US-20140322150-A1 | PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION | TYR, MC1R, MITF | AGTR1 895/4885MEN1 2910/4885NPC1 810/4885 |
| US-20120258063-A1 | PREVENTING OR AMELIORATING AGENT FOR PIGMENTATION | TYR, MC1R, MITF | AGTR1 895/4885MEN1 2910/4885NPC1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.