Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL385936 | 0.89 | GPR119 (0.50) | KDRTBK1IKBKEGPR119 | |
| SCHEMBL4719349 | 0.85 | GPR119 (0.46) | TBK1IKBKEGPR119ARCDK2 | |
| SCHEMBL4723643 | 0.84 | FLT3 (0.38) | KDRGPR119EGFRCDK2FLT3 | |
| SCHEMBL4723304 | 0.82 | GPR119 (0.42) | KDRGPR119ERBB2CDK2FLT3 | |
| SCHEMBL4719350 | 0.81 | GPR119 (0.40) | GPR119SCN9ACDK2FLT3CDK6 | |
| SCHEMBL4723151 | 0.81 | GPR119 (0.44) | TBK1IKBKEGPR119CDK2CDK6 | |
| SCHEMBL4719882 | 0.81 | ERBB2 (0.39) | KDRTBK1IKBKEGPR119ERBB2 | |
| SCHEMBL4721904 | 0.81 | TRPV1 (0.44) | GPR119CDK2FLT3CDK6 | |
| SCHEMBL4720714 | 0.81 | GPR119 (0.40) | GPR119ERBB2EGFRCDK2FLT3 | |
| SCHEMBL4720846 | 0.81 | GPR119 (0.41) | KDRGPR119CDK2FLT3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |