Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389127 | 0.89 | TBK1 (0.44) | SYKALDH1A1KDM4ETBK1GPR119 | |
| SCHEMBL4719783 | 0.86 | TBK1 (0.39) | TBK1ACACBGPR119S1PR1CYP3A4 | |
| SCHEMBL4722459 | 0.83 | TBK1 (0.38) | SYKTBK1BRAFACACBGPR119 | |
| SCHEMBL4719368 | 0.83 | TBK1 (0.38) | SYKTBK1BRAFACACBGPR119 | |
| SCHEMBL4721914 | 0.83 | GPR119 (0.46) | TBK1GPR119S1PR1 | |
| SCHEMBL4722994 | 0.82 | GPR119 (0.39) | TBK1ACACBGPR119S1PR1CYP3A4 | |
| SCHEMBL4721660 | 0.82 | GPR119 (0.40) | KDM4ETBK1ACACBGPR119S1PR1 | |
| SCHEMBL4721883 | 0.82 | CDK1 (0.40) | TBK1ACACBTGFBR1GPR119S1PR1 | |
| SCHEMBL4721012 | 0.82 | TBK1 (0.38) | SYKTBK1BRAFACACBGPR119 | |
| SCHEMBL4723296 | 0.81 | TBK1 (0.39) | SYKTBK1ACACBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |