Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KHK | P50053 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29353981 | 0.88 | NPSR1 (1.00) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL10295 | 0.88 | NPSR1 (1.00) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL27974001 | 0.83 | NPSR1 (0.89) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| Diphenylether SCHEMBL4184182 | 0.77 | NPSR1 (0.77) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL4374246 | 0.77 | NPSR1 (0.78) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL27840000 | 0.75 | NPSR1 (0.75) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL9960528 | 0.75 | NPSR1 (0.75) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| Pyrrolidine SCHEMBL4830345 | 0.75 | RAB9A (0.54) | NPSR1ALDH1A1KDM4EPKMGAA | |
| SCHEMBL23854433 | 0.74 | NPSR1 (0.72) | NPSR1ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL5015526 | 0.74 | NPSR1 (0.72) | NPSR1ALDH1A1KDM4EMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |