Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | SLC2A1 | P11166 | 1/20 | 1.00 |
| ▸ | APOBEC3A | P31941 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 1.00 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.66 |
| ▸ | HRH1 | P35367 | 2/20 | 0.66 |
| ▸ | TERT | O14746 | 1/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31087715 | 1.00 | RAD52 (1.00) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL3952873 | 0.88 | RAD52 (0.78) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL14388990 | 0.86 | RAD52 (0.75) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL17423250 | 0.86 | RAD52 (0.74) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL10313327 | 0.85 | RAD52 (0.73) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL4726253 | 0.84 | CACNA2D1 (0.91) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL5578493 | 0.84 | POLB (0.79) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL7869214 | 0.84 | POLB (0.79) | RAD52POLBRAB9ANPC1SLC2A1 | |
| Hydrochloric Acid SCHEMBL2683722 | 0.83 | CACNA2D1 (0.89) | RAD52POLBRAB9ANPC1SLC2A1 | |
| SCHEMBL17423304 | 0.83 | KMT2A (0.69) | RAD52POLBRAB9ANPC1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010984-A9 | ACRIDINE ACTIVATION OF P53 AND USES THEREOF | UNIV PENNSYLVANIA (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008010984-A2 | ACRIDINE ACTIVATION OF P53 AND USES THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-24 | — | — | WO | claimed |
| EP-1854509-A2 | Methods and compositions for restoring conformational stability of a protein of the p53 family | Pfizer Products Inc. (US) | 2007-11-14 | — | — | EP | claimed |
| EP-1137418-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | claimed |
| WO-2000032175-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | PFIZER PRODUCTS INC. (US) | 2000-06-08 | — | — | WO | claimed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| WO-2008010984-A9 | ACRIDINE ACTIVATION OF P53 AND USES THEREOF | UNIV PENNSYLVANIA (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008010984-A2 | ACRIDINE ACTIVATION OF P53 AND USES THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-24 | — | — | WO | disclosed |
| EP-1854509-A2 | Methods and compositions for restoring conformational stability of a protein of the p53 family | Pfizer Products Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1137418-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000032175-A2 | METHODS AND COMPOSITIONS FOR RESTORING CONFORMATIONAL STABILITY OF A PROTEIN OF THE p53 FAMILY | PFIZER PRODUCTS INC. (US) | 2000-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | KEAP1, TXNRD1, NFE2L2 | RAD52 2325/4885POLB 3935/4885RAB9A 3361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.