Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726632 | 0.93 | CDC7 (0.41) | CDC7APPMAP4K4NOS1NOS3 | |
| SCHEMBL6422468 | 0.79 | GRM5 (0.42) | CSNK1A1HPGDSL3MBTL1GSK3BKDM4E | |
| SCHEMBL1035242 | 0.79 | ALDH1A1 (0.47) | APPCSNK1A1HPGDSPIN1PIK3CA | |
| SCHEMBL13668590 | 0.79 | PIN1 (0.40) | APPMAP4K4DAPK3PRKACALTK | |
| SCHEMBL15690528 | 0.79 | HTT (0.44) | CDC7MAP4K4NOS1NOS3HPGDS | |
| SCHEMBL11157078 | 0.75 | HPGDS (0.47) | CDC7APPMAP4K4DAPK3PRKACA | |
| SCHEMBL15567034 | 0.74 | ABCB1 (0.45) | MAP4K4DAPK3PRKACALTKMAPK8 | |
| SCHEMBL5873739 | 0.74 | PLAU (0.57) | CDC7NOS1NOS3CDK2 | |
| SCHEMBL15197891 | 0.72 | PIN1 (0.42) | APPCSNK1A1PIN1GSK3BKDM4E | |
| SCHEMBL622637 | 0.72 | CDK5 (0.47) | CDC7MAP4K4DAPK3PRKACALTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220556-A2 | HETEROCYCLIC SUMO1 SMALL MOLECULE DEGRADERS AND USE THEREOF | HB THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| WO-2008015423-A1 | QUINOLINE AND QUINOXALINE N-OXIDES AS CHK-1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008015423-A1 | QUINOLINE AND QUINOXALINE N-OXIDES AS CHK-1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |