Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 6/20 | 0.34 |
| ▸ | PPARD | Q03181 | 6/20 | 0.34 |
| ▸ | PPARA | Q07869 | 6/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135244 | 1.00 | CES2 (0.38) | CES2CES1PLA2G2APLA2G5DDAH1 | |
| SCHEMBL7312353 | 0.77 | CES1 (0.46) | CES2CES1ALDH1A1AKR1B1TP53 | |
| SCHEMBL4679170 | 0.74 | CES1 (0.42) | CES2CES1DDAH1ALDH1A1AKR1B1 | |
| SCHEMBL7309900 | 0.71 | CES2 (0.48) | CES2CES1ALDH1A1AKR1B1MAPK1 | |
| SCHEMBL8393264 | 0.69 | CES2 (0.50) | CES2CES1ALDH1A1MAPK1PPARG | |
| SCHEMBL4521252 | 0.68 | CES2 (0.44) | CES2CES1ALDH1A1AKR1B1MAPK1 | |
| SCHEMBL6970922 | 0.67 | CES1 (0.44) | CES2CES1ALDH1A1AKR1B1TP53 | |
| SCHEMBL840697 | 0.67 | — | — | |
| SCHEMBL543757 | 0.67 | CES1 (0.55) | CES2CES1ALDH1A1AKR1B1TP53 | |
| SCHEMBL9560717 | 0.66 | CES1 (0.48) | CES2CES1ALDH1A1AKR1B1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7385062-B2 | Process for the preparation of phenyltetrazole derivatives | DIPHARMA S.P.A. (IT) | 2008-06-10 | — | — | US | claimed |
| WO-2008012852-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTS | S.I.M.S. S.r.l. - SOCIETÀ ITALIANA MEDICINALI SCANDICCI (IT) | 2008-01-31 | — | — | WO | claimed |
| EP-1660463-B1 | A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES | DIPHARMA FRANCIS SRL (IT) | 2007-12-05 | — | — | EP | claimed |
| US-20070093540-A1 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS | DIPHARMA S.P.A. (IT) | 2007-04-26 | — | — | US | claimed |
| EP-1777224-A2 | A process for the preparation of angiotensin II antagonistic compounds | Dipharma S.p.A. (IT) | 2007-04-25 | — | — | EP | claimed |
| JP-2007501770-A | — | — | 2007-02-01 | — | — | JP | claimed |
| US-20060183916-A1 | Process for the preparation of phenyltetrazole derivatives | DIPHARMA S.P.A. (IT) | 2006-08-17 | — | — | US | claimed |
| EP-1660463-A1 | A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES | Dipharma S.p.A. (IT) | 2006-05-31 | — | — | EP | claimed |
| WO-2005014560-A1 | A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES | DIPHARMA S.P.A. (IT) | 2005-02-17 | — | — | WO | claimed |
| US-7385062-B2 | Process for the preparation of phenyltetrazole derivatives | DIPHARMA S.P.A. (IT) | 2008-06-10 | — | — | US | disclosed |
| WO-2008012852-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTS | S.I.M.S. S.r.l. - SOCIETÀ ITALIANA MEDICINALI SCANDICCI (IT) | 2008-01-31 | — | — | WO | disclosed |
| EP-1660463-B1 | A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES | DIPHARMA FRANCIS SRL (IT) | 2007-12-05 | — | — | EP | disclosed |
| US-20070093540-A1 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS | DIPHARMA S.P.A. (IT) | 2007-04-26 | — | — | US | disclosed |
| EP-1777224-A2 | A process for the preparation of angiotensin II antagonistic compounds | Dipharma S.p.A. (IT) | 2007-04-25 | — | — | EP | disclosed |
| EP-1660463-A1 | A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES | Dipharma S.p.A. (IT) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005014560-A1 | A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES | DIPHARMA S.P.A. (IT) | 2005-02-17 | — | — | WO | disclosed |
| EP-0994881-B1 | ORTHO-METALATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL)BENZENES | ZAMBON SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-6271375-B1 | ESPECIALLY PREPARATION OF TASOSARTAN; GRIGNARD REAGENTS | ZAMBON GROUP S.P.A. (IT) | 2001-08-07 | — | — | US | disclosed |
| EP-0994881-A1 | ORTHO-METALATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL)BENZENES | ZAMBON GROUP S.p.A. (IT) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001459-A1 | ORTHO-METALATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL)BENZENES | ZAMBON GROUP S.P.A. (IT) | 1999-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093540-A1 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II ANTAGONISTIC COMPOUNDS | AGTR2, AGTR1, ACE2 | CES2 2201/4885CES1 2437/4885PLA2G2A 1985/4885 |
| US-20060183916-A1 | Process for the preparation of phenyltetrazole derivatives | AGTR2, ACE, AGTR1 | CES2 2978/4885CES1 3467/4885PLA2G2A 4550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.