Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19602565 | 0.82 | CA1 (0.39) | LMNAHTTNR1I2TAS2R14 | |
| SCHEMBL924868 | 0.81 | NPC1 (0.38) | MAPK1KMT2AMEN1TAS2R14MAPT | |
| SCHEMBL5281121 | 0.81 | TAS2R14 (0.40) | KMT2AMEN1CNR2TAS2R14MAPT | |
| SCHEMBL5425396 | 0.81 | POLB (0.41) | MAPK1KMT2AMEN1TAS2R14MAPT | |
| SCHEMBL31378586 | 0.80 | L3MBTL1 (0.48) | KMT2AMEN1TDP1L3MBTL1MAPT | |
| SCHEMBL5425873 | 0.79 | POLB (0.37) | MAPK1KMT2ALMNATAS2R14MAPT | |
| SCHEMBL5429167 | 0.77 | CYP4F2 (0.38) | KMT2ALMNAMEN1CNR2TAS2R14 | |
| SCHEMBL5108292 | 0.76 | NPSR1 (0.42) | MAPK1LMNANR1I2L3MBTL1MAPT | |
| SCHEMBL17593041 | 0.76 | NR3C1 (0.47) | MAPK1KMT2ALMNANR1I2TSHR | |
| SCHEMBL30871416 | 0.74 | ALDH1A1 (0.44) | KMT2AHTTMEN1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497261-B1 | PHENETHANOLAMINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-12-19 | — | — | EP | disclosed |
| EP-1425001-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003024439-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-03-27 | — | — | WO | disclosed |