Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528744 | 0.89 | HPGD (0.45) | TDP1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4512792 | 0.86 | TAAR1 (0.43) | MEN1KMT2ASMN1; SMN2LPAR1LMNA | |
| SCHEMBL23120228 | 0.84 | TDP1 (0.54) | TDP1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4730554 | 0.83 | MEN1 (0.44) | TDP1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL26985835 | 0.83 | TDP1 (0.53) | TDP1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4522949 | 0.83 | KMT2A (0.48) | TDP1MEN1KMT2AGAAHDAC1 | |
| SCHEMBL1181113 | 0.82 | TAAR1 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8989751 | 0.82 | TDP1 (0.43) | TDP1KMT2ALMNA | |
| SCHEMBL4519273 | 0.82 | LTB4R (0.41) | NPC1RAB9AKMT2AALOX5SMN1; SMN2 | |
| SCHEMBL4524217 | 0.82 | L3MBTL1 (0.41) | TDP1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041914-A1 | 5-(2-AMINO-L-HYDROXYETHYL)-8-HYDROXY-2-OXOQUINOLINE DERIVATIVES AND OTHER COMPOUNDS AS β2 -ADRENERGIC AGONISTS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |