Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533716 | 0.89 | LMNA (0.35) | MEN1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL4529767 | 0.86 | TAAR1 (0.42) | MEN1KMT2AHDAC1SMN1; SMN2LMNA | |
| SCHEMBL4514375 | 0.84 | HDAC1 (0.43) | MEN1KMT2ATDP1HDAC1HDAC8 | |
| SCHEMBL1180759 | 0.83 | TAAR1 (0.39) | NPC1RAB9ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL4532458 | 0.83 | L3MBTL1 (0.39) | MEN1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL4726672 | 0.83 | TDP1 (0.46) | MEN1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL7455663 | 0.82 | CA2 (0.54) | CA2HDAC1HDAC3MAPK1ADRA1A | |
| SCHEMBL4520076 | 0.80 | SIGMAR1 (0.55) | SLC6A3 | |
| SCHEMBL4524941 | 0.79 | PTPRC (0.36) | SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL5933377 | 0.78 | TDP1 (0.66) | MEN1NPC1RAB9AKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041914-A1 | 5-(2-AMINO-L-HYDROXYETHYL)-8-HYDROXY-2-OXOQUINOLINE DERIVATIVES AND OTHER COMPOUNDS AS β2 -ADRENERGIC AGONISTS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |