Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.50 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807655 | 0.88 | CACNA1G (0.45) | SMN1; SMN2CACNA1GCACNA1HCACNA1INPC1 | |
| SCHEMBL26202213 | 0.86 | CACNA1G (0.54) | SMN1; SMN2CACNA1GCACNA1HCACNA1INPC1 | |
| SCHEMBL4288842 | 0.84 | HDAC1 (0.56) | SMN1; SMN2CACNA1GCACNA1HCACNA1INPC1 | |
| SCHEMBL31220195 | 0.84 | CACNA1G (0.53) | CACNA1GCACNA1HCACNA1INPC1RAB9A | |
| SCHEMBL4672568 | 0.77 | CACNA1G (0.47) | SMN1; SMN2CACNA1GCACNA1HCACNA1INPC1 | |
| SCHEMBL27785815 | 0.77 | CACNA1G (0.47) | SMN1; SMN2CACNA1GCACNA1HCACNA1INPC1 | |
| SCHEMBL15964859 | 0.77 | SCD (0.59) | SMN1; SMN2NPC1RAB9AHDAC1LMNA | |
| SCHEMBL4324414 | 0.76 | ALDH1A1 (0.54) | SMN1; SMN2NPC1RAB9ATSHRLMNA | |
| SCHEMBL28136392 | 0.76 | KMT2A (0.51) | SMN1; SMN2CACNA1GCACNA1HCACNA1INPC1 | |
| SCHEMBL2823500 | 0.76 | TDP1 (0.43) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573006-A | Heterocyclic amides of RIP1 kinase inhibitors as pharmaceuticals | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-04-19 | — | — | CN | disclosed |
| WO-2008027442-A2 | ABUSE DETERRENT ORAL PHARMACEUTICAL FORMULATIONS OF OPIOID AGONISTS AND METHOD OF USE | THERAQUEST BIOSCIENCES, LLC (US) | 2008-03-06 | — | — | WO | disclosed |