Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | BCL9 | O00512 | 3/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44971 | 0.89 | MEN1 (0.41) | PRKAG1PRKAA1PRKAB1GHSRMGLL | |
| SCHEMBL45124 | 0.89 | PRKAG1 (0.52) | PRKAG1PRKAA1PRKAB1HSD11B1GHSR | |
| SCHEMBL11029216 | 0.85 | PRKAG1 (0.41) | PRKAG1PRKAA1PRKAB1HSD11B1KDM4E | |
| SCHEMBL42376 | 0.84 | PRKAG1 (0.42) | PRKAG1PRKAA1PRKAB1HSD11B1KDM4E | |
| SCHEMBL45267 | 0.84 | PRKAG1 (0.46) | PRKAG1PRKAA1PRKAB1HSD11B1GHSR | |
| SCHEMBL11025816 | 0.81 | PRKAG1 (0.40) | PRKAG1PRKAA1PRKAB1MGLLKDM4E | |
| SCHEMBL11940877 | 0.79 | SCN9A (0.39) | PRKAG1PRKAA1PRKAB1MAPTAKT1 | |
| SCHEMBL45015 | 0.79 | MAPT (0.40) | PRKAG1PRKAA1PRKAB1MEN1MAPT | |
| SCHEMBL11027687 | 0.79 | PRKAG1 (0.38) | PRKAG1PRKAA1PRKAB1KDM4EMAPT | |
| SCHEMBL45014 | 0.78 | HTR1A (0.39) | PRKAG1PRKAA1PRKAB1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004218-A1 | NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-01-05 | — | — | US | disclosed |
| US-20120004218-A1 | NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-01-05 | — | — | US | disclosed |
| WO-2012001020-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004218-A1 | NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES | GPR119, PRKAB1, PRKAG1 | PRKAG1 3/4885PRKAA1 5/4885PRKAB1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.