Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.61 |
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.55 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842127 | 0.86 | ALDH1A1 (0.57) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL4728696 | 0.81 | KDM4E (0.48) | NPC1RAB9AALDH1A1ALDH1A3KDM4E | |
| SCHEMBL1691409 | 0.77 | RAB9A (1.00) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL1691254 | 0.76 | NPC1 (0.80) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL4728088 | 0.76 | RAB9A (0.61) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL13198279 | 0.74 | RAB9A (0.73) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL4725742 | 0.74 | APP (0.72) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL1664803 | 0.73 | RAB9A (0.83) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL217156 | 0.72 | RAB9A (0.75) | NPC1RAB9AALDH1A1ALDH1A3APP | |
| SCHEMBL1472541 | 0.72 | ALDH1A1 (0.82) | NPC1RAB9AALDH1A1ALDH1A3APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |