Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL594366 | 0.85 | ALDH1A1 (0.57) | TTRHCAR1KDM4EALDH1A1HPGD | |
| SCHEMBL594127 | 0.83 | KDM4E (0.56) | TTRHCAR1KDM4EALDH1A1HPGD | |
| SCHEMBL592613 | 0.83 | KDM4E (0.56) | TTRHCAR1KDM4EALDH1A1HPGD | |
| SCHEMBL19404305 | 0.81 | TTR (0.56) | TTRHCAR1KDM4EALDH1A1HPGD | |
| SCHEMBL593762 | 0.81 | KMO (0.60) | TTRHCAR1ALDH1A1HPGDKMO | |
| SCHEMBL593990 | 0.81 | TTR (0.53) | TTRHCAR1KDM4EALDH1A1HPGD | |
| SCHEMBL30853515 | 0.80 | LGMN (0.46) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL20577868 | 0.80 | ADRB1 (0.44) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL593527 | 0.78 | USP2 (0.60) | TTRHCAR1KDM4EALDH1A1HPGD | |
| SCHEMBL28587988 | 0.77 | ALDH1A1 (0.38) | TTRKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |