Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520879 | 0.70 | APLNR (0.37) | MEN1KMT2A | |
| SCHEMBL18992124 | 0.65 | PKM (0.50) | TDP1PKMKMT2A | |
| SCHEMBL2329819 | 0.64 | KMT2A (0.32) | TDP1KMT2A | |
| SCHEMBL16038530 | 0.63 | — | — | |
| SCHEMBL4214351 | 0.63 | — | — | |
| SCHEMBL29090009 | 0.61 | TDP1 (0.34) | TDP1 | |
| SCHEMBL29464166 | 0.61 | PKM (0.32) | PKM | |
| Hydrochloric Acid SCHEMBL31074189 | 0.61 | — | — | |
| SCHEMBL14470773 | 0.61 | — | — | |
| SCHEMBL20672666 | 0.60 | PKM (0.61) | PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045978-A1 | PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | WO | claimed |
| WO-2008045978-A1 | PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | WO | disclosed |