Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 3/20 | 0.44 |
| ▸ | RARB | P10826 | 2/20 | 0.44 |
| ▸ | RARG | P13631 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729406 | 1.00 | PKM (0.46) | PKMCNR2RARARARBRARG | |
| SCHEMBL5509233 | 0.81 | ABCG2 (0.52) | ABCG2MEN1KMT2ATNFRSF1AABCB1 | |
| SCHEMBL6093635 | 0.80 | CNR2 (0.55) | CNR2MAPTLMNANPC1ALDH1A1 | |
| SCHEMBL5505975 | 0.79 | MEN1 (0.58) | CNR2ABCG2MAPTLMNANPC1 | |
| SCHEMBL5504502 | 0.78 | ABCG2 (0.50) | CNR2ABCG2MEN1KMT2A | |
| SCHEMBL5510873 | 0.78 | ABCG2 (0.56) | ABCG2MAPTLMNAMEN1KMT2A | |
| SCHEMBL4598670 | 0.75 | PKM (0.49) | PKMCNR2RARARARBRARG | |
| SCHEMBL4726425 | 0.75 | MAOA (0.47) | CNR2MAPTLMNAMEN1KMT2A | |
| SCHEMBL4729401 | 0.75 | MAOA (0.47) | CNR2MAPTLMNAMEN1KMT2A | |
| SCHEMBL8649937 | 0.75 | RARA (0.60) | PKMCNR2RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |