Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29750394 | 1.00 | LOXL2 (0.58) | LOXL2HRH4MTNR1AMTNR1BHRH3 | |
| SCHEMBL7067817 | 0.84 | LOXL2 (0.50) | LOXL2HRH4MTNR1AMTNR1BHRH3 | |
| SCHEMBL28545346 | 0.84 | LOXL2 (0.62) | LOXL2HRH4MTNR1AMTNR1BHRH3 | |
| SCHEMBL16771656 | 0.82 | LOXL2 (0.51) | LOXL2HRH4MTNR1AMTNR1BAHR | |
| SCHEMBL30594269 | 0.82 | LOXL2 (0.51) | LOXL2HRH4MTNR1AMTNR1BAHR | |
| SCHEMBL8570896 | 0.81 | LOXL2 (0.55) | LOXL2HRH4MTNR1AMTNR1BHRH3 | |
| SCHEMBL8574842 | 0.81 | LOXL2 (0.55) | LOXL2HRH4MTNR1AMTNR1BHRH3 | |
| SCHEMBL29368759 | 0.79 | PYCR1 (0.54) | LOXL2HRH4 | |
| SCHEMBL108061 | 0.78 | LOXL2 (0.64) | LOXL2HRH4MTNR1AMTNR1BHRH3 | |
| SCHEMBL29375490 | 0.78 | LOXL2 (0.64) | LOXL2HRH4MTNR1AMTNR1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506532-A1 | Indole derivatives, process for their preparation and medicaments containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1992-09-30 | — | — | EP | claimed |
| US-12281099-B2 | Isoindolinone substituted indoles and derivatives as RAS inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-04-22 | — | — | US | disclosed |
| EP-3931188-B1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-08-30 | — | — | EP | disclosed |
| EP-3931188-B1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220144810-A1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | US | disclosed |
| US-20220144810-A1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | US | disclosed |
| CN-109422754-A | Pyrazolo [3,4-d] pyrimidine -3- ketone derivatives, its pharmaceutical composition and application | 上海迪诺医药科技有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-109364004-A | A kind of skin-care gel containing Maltsupex | 拉芳家化股份有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-106905300-B | Giantreed alkali derivant and its pharmaceutical composition and its application in pharmacy | 中国科学院昆明植物研究所 | 2019-01-22 | — | — | CN | disclosed |
| CN-107174586-A | Using giantreed alkali derivant as the pharmaceutical composition of active component and its application | 中国科学院昆明植物研究所 | 2017-09-19 | — | — | CN | disclosed |
| EP-0985674-A1 | ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-15 | — | — | EP | disclosed |
| EP-0695755-B1 | Pyrrolocarbazole | HOFFMANN LA ROCHE (CH) | 1998-10-21 | — | — | EP | disclosed |
| US-5721267-A | ANTICANCER AGENTS | SYNTEX (U.S.A.) INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0695755-A1 | Pyrrolocarbazoles | F. Hoffmann-La Roche AG (CH) | 1996-02-07 | — | — | EP | disclosed |
| US-5219859-A | Chloesterol acyltransferase inhibitors; antilipemic agents; antidiabetic agents; atherosclerosis | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1993-06-15 | — | — | US | disclosed |
| EP-0506532-A1 | Indole derivatives, process for their preparation and medicaments containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1992-09-30 | — | — | EP | disclosed |
| EP-0037271-B1 | INDOLE DERIVATIVES AND PROCESS FOR PREPARING THE SAME | TORAY INDUSTRIES, INC. (JP) | 1984-01-18 | — | — | EP | disclosed |
| US-4399289-A | STABLE TRYPTOPHANE INTERMEDIATES | TORAY INDUSTRIES, INC. (JP) | 1983-08-16 | — | — | US | disclosed |
| EP-0037271-A1 | Indole derivatives and process for preparing the same | TORAY INDUSTRIES, INC. (JP) | 1981-10-07 | — | — | EP | disclosed |
| US-4154735-A | FUNGICIDES, DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281099-B2 | Isoindolinone substituted indoles and derivatives as RAS inhibitors | NRAS, KRAS, RASSF5 | LOXL2 4662/4885HRH4 1330/4885MTNR1A 1048/4885 |
| US-20220144810-A1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | NRAS, RASSF5, KRAS | LOXL2 4649/4885HRH4 1268/4885MTNR1A 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.