Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 6/20 | 0.40 |
| ▸ | RAF1 | P04049 | 5/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729210 | 0.88 | TRPV1 (0.42) | BRAFRAF1TRPV1HDAC6HDAC3 | |
| SCHEMBL14292743 | 0.88 | TRPV1 (0.39) | BRAFRAF1TRPV1HDAC6HDAC3 | |
| SCHEMBL4729484 | 0.88 | TRPV1 (0.41) | BRAFRAF1TRPV1SIRT2SIRT1 | |
| SCHEMBL4729212 | 0.88 | TRPV1 (0.41) | BRAFRAF1TRPV1HDAC6HDAC3 | |
| SCHEMBL4730164 | 0.86 | MAPK14 (0.53) | BRAFRAF1 | |
| SCHEMBL4726088 | 0.85 | RAF1 (0.41) | BRAFRAF1TRPV1HDAC6HDAC3 | |
| SCHEMBL4729438 | 0.85 | MEN1 (0.54) | BRAFRAF1TRPV1HDAC6HDAC3 | |
| SCHEMBL4781066 | 0.84 | MAPK14 (0.55) | RAF1 | |
| SCHEMBL4726226 | 0.84 | RAF1 (0.46) | BRAFRAF1TRPV1HDAC6HDAC3 | |
| SCHEMBL4726798 | 0.83 | RAF1 (0.42) | BRAFRAF1TRPV1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |