Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | BUB1 | O43683 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.53 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.53 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781066 | 0.90 | MAPK14 (0.55) | MAPK14HSPB1EPHA3FRKRAF1 | |
| SCHEMBL4729210 | 0.88 | TRPV1 (0.42) | MAPK14EPHA3FRKRAF1BRAF | |
| SCHEMBL4729484 | 0.88 | TRPV1 (0.41) | MAPK14EPHA3FRKRAF1BRAF | |
| SCHEMBL4729212 | 0.88 | TRPV1 (0.41) | MAPK14EPHA3FRKRAF1BRAF | |
| SCHEMBL4729549 | 0.86 | BTK (0.40) | RAF1BRAF | |
| SCHEMBL4729438 | 0.85 | MEN1 (0.54) | RAF1BRAF | |
| SCHEMBL14292743 | 0.84 | TRPV1 (0.39) | MAPK14EPHA3FRKRAF1BRAF | |
| SCHEMBL4726226 | 0.84 | RAF1 (0.46) | CYP2C9RAF1BRAF | |
| SCHEMBL4784220 | 0.84 | MAPK14 (0.42) | MAPK14MAPK11HSPB1EPHA3FRK | |
| SCHEMBL4726798 | 0.83 | RAF1 (0.42) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |