Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725583 | 0.84 | CCNT1 (0.41) | TRPV1CTSA | |
| SCHEMBL4728068 | 0.81 | CTSA (0.38) | CTSA | |
| SCHEMBL15836878 | 0.80 | CTSA (0.39) | CTSACNR2ADAMTS5TNF | |
| SCHEMBL4727667 | 0.78 | FAAH (0.46) | TRPV1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4779882 | 0.78 | TRPV3 (0.45) | TRPV1TRPV3 | |
| SCHEMBL4727785 | 0.76 | CCNT1 (0.46) | AURKATRPV1CTSATRPV3 | |
| SCHEMBL4729366 | 0.76 | SLC10A1 (0.36) | TSHRALOX15 | |
| SCHEMBL15492016 | 0.73 | AURKA (0.64) | AURKATRPV1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL27738470 | 0.73 | NTRK1 (0.48) | TRPV1MEN1KMT2A | |
| SCHEMBL4780128 | 0.72 | CCNT1 (0.43) | AURKATRPV1CTSAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |