Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.45 |
| ▸ | PTPRF | P10586 | 6/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730478 | 0.81 | GAA (0.41) | ALOX5GGPS1PTPRFPTPN2PTPN1 | |
| SCHEMBL4728155 | 0.77 | PTPRF (0.40) | ALOX5GGPS1PTPRFPTPN2PTPN1 | |
| SCHEMBL12996512 | 0.77 | ALOX5 (0.71) | ALOX5GGPS1PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL15855421 | 0.75 | ALOX5 (0.69) | ALOX5GGPS1PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL12996525 | 0.75 | ALOX5 (0.69) | ALOX5GGPS1PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL13986662 | 0.75 | GGPS1 (0.61) | ALOX5GGPS1PRMT5WDR77PTGES2 | |
| SCHEMBL431478 | 0.74 | ALOX5 (0.67) | ALOX5GGPS1PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL4728156 | 0.74 | ALOX5 (0.50) | ALOX5GGPS1PTPRFPTPN2PTPN1 | |
| SCHEMBL16405875 | 0.73 | ALOX5 (0.58) | ALOX5GGPS1PRMT5WDR77GAA | |
| SCHEMBL14260764 | 0.73 | ALOX5 (0.49) | ALOX5GGPS1PTPRFPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |