Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRF | P10586 | 6/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729410 | 0.77 | ALOX5 (0.49) | PTPRFPTPN2PTPN1GAAGGPS1 | |
| SCHEMBL4730478 | 0.74 | GAA (0.41) | PTPRFPTPN2PTPN1GAARAB9A | |
| SCHEMBL9721952 | 0.73 | NR4A2 (0.61) | GAAPPARAMAPTRAB9APPARG | |
| SCHEMBL16395418 | 0.67 | ALOX5 (0.58) | MAPTGGPS1ALOX5PRMT5WDR77 | |
| SCHEMBL16405834 | 0.67 | ALOX5 (0.58) | MAPTGGPS1ALOX5PRMT5WDR77 | |
| SCHEMBL16405924 | 0.67 | ALOX5 (0.58) | MAPTGGPS1ALOX5PRMT5WDR77 | |
| SCHEMBL4728156 | 0.67 | ALOX5 (0.50) | PTPRFPTPN2PTPN1MAPTGGPS1 | |
| SCHEMBL21168062 | 0.66 | ALOX5 (0.57) | MAPTGGPS1ALOX5PRMT5WDR77 | |
| SCHEMBL21563826 | 0.66 | ALOX5 (0.57) | MAPTGGPS1ALOX5PRMT5WDR77 | |
| SCHEMBL17232186 | 0.66 | ALOX5 (0.57) | MAPTGGPS1ALOX5PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |