Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
| ▸ | PTPRF | P10586 | 7/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 7/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729410 | 0.81 | ALOX5 (0.49) | GAAKDM4ESMN1; SMN2ALOX5GGPS1 | |
| SCHEMBL4859050 | 0.80 | ALOX5 (0.48) | ALOX5GGPS1 | |
| SCHEMBL14260809 | 0.79 | PPARG (0.44) | GGPS1SHMT1SHMT2 | |
| SCHEMBL4730467 | 0.79 | PPARG (0.44) | GGPS1SHMT1SHMT2 | |
| SCHEMBL4731059 | 0.77 | PPARG (0.36) | GAAKDM4EALOX5GGPS1SHMT1 | |
| SCHEMBL14260756 | 0.76 | CCR2 (0.36) | GAAKDM4EALOX5GGPS1PTPRF | |
| SCHEMBL4459051 | 0.75 | CYP2C19 (0.51) | ALOX5GGPS1 | |
| SCHEMBL4728155 | 0.74 | PTPRF (0.40) | GAAALOX5GGPS1PTPRFPTPN2 | |
| SCHEMBL14260755 | 0.73 | PPARG (0.47) | GAAPTPN1PRNPRAB9A | |
| SCHEMBL4856992 | 0.70 | GGPS1 (0.54) | GAAALOX5GGPS1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033934-A1 | SUBSTITUTED HETEROARYL CARBOXYLIC ACID DERIVATIVES AS PTB-1B INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |