Succinic Acid

Succinic Acid

SCHEMBL4729943

CC[P+](CC)(CC)Cc1ccccc1.CC[P+](CC)(CC)Cc1ccccc1.O=C([O-])CCC(=O)[O-]

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49
HDAC5 Q9UQL6 1/20 0.49
ALPL P05186 1/20 0.46
POLB P06746 1/20 0.46
ALPG P10696 1/20 0.46
CYP1A2 P05177 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
TRPA1 O75762 1/20 0.41
ALDH1A1 P00352 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL10776778 0.89 ALPL (0.49) ALPLPOLBALPGCYP1A2CES2
SCHEMBL17438851 0.84 POLB (0.45) ALPLPOLBALPGCYP1A2CES2
SCHEMBL17438707 0.81 MMP8 (0.47) ALPLPOLBALPGALDH1A1SMN1; SMN2
Iodide SCHEMBL5086624 0.80 TP53 (0.48) CYP1A2TRPA1
Fluoride Ion SCHEMBL5246642 0.80 TP53 (0.48) CYP1A2TRPA1
Hydrochloric Acid SCHEMBL2685431 0.80 TP53 (0.48) TRPA1ALDH1A1
Water SCHEMBL7721938 0.80 TP53 (0.48) CYP1A2TRPA1
Bromide SCHEMBL5088078 0.80 TP53 (0.48) TRPA1
SCHEMBL237969 0.80 ALPL (0.41) ALPLPOLBALPGCYP1A2CES2
SCHEMBL486291 0.80 ALPL (0.41) ALPLPOLBALPGCYP1A2TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008045894-A1 SOLUBLE POLYMERS WITH LOW CONVERSION OF ACIDS FROM AROMATIC EPOXY RESINS AND DIACIDS AND CROSSLINKED COATINGS PREPARED THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2008-04-17 WO disclosed
WO-2008045889-A1 PROCESS FOR PREPARING SOLUBLE POLYMERS WITH LOW CONVERSION OF ACID FROM AROMATIC EPOXY RESINS AND DIACIDS AND PROCESS FOR PREPARING CROSSLINKED COATINGS THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2008-04-17 WO disclosed