Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 15/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196478 | 0.85 | HTR1A (0.52) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL4375168 | 0.84 | HTR1A (0.55) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL4998334 | 0.84 | HTR1A (0.55) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL4363794 | 0.84 | HTR1A (0.55) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL13927903 | 0.83 | HTR1A (0.56) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL4782511 | 0.82 | HTR1A (0.48) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL4907152 | 0.82 | HTR1A (0.55) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL4197898 | 0.82 | HTR1A (0.55) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL13950879 | 0.82 | HTR1A (0.55) | LMNAHTR1ACYP3A4CYP2C8DRD2 | |
| SCHEMBL4778919 | 0.81 | HTR1A (0.47) | HTR1ACYP3A4CYP2C8DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139546-A1 | Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines | WYETH (US) | 2008-06-12 | — | — | US | disclosed |
| WO-2008042735-A1 | TETRAHYDROQUINOLINE, INDOLINE, AND RELATED ANILINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH (US) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139546-A1 | Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines | HTR5A, HTR2C, HTR3A | LMNA 2479/4885HTR1A 6/4885CYP3A4 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.