Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363794 | 1.00 | HTR1A (0.55) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL4998334 | 1.00 | HTR1A (0.55) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL13927903 | 0.88 | HTR1A (0.56) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL4907152 | 0.87 | HTR1A (0.55) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL13950879 | 0.87 | HTR1A (0.55) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL4197898 | 0.87 | HTR1A (0.55) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL5508210 | 0.86 | HTR1A (0.54) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL4483963 | 0.86 | HTR1A (0.54) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL14196481 | 0.85 | HTR1A (0.53) | HTR1ACYP3A4CYP2C8DRD2DRD4 | |
| SCHEMBL4729997 | 0.84 | LMNA (0.52) | HTR1ACYP3A4CYP2C8DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7439364-B2 | Process for the synthesis of derivatives of halo-[2,3-F] quinoline | WYETH (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439364-B2 | Process for the synthesis of derivatives of halo-[2,3-F] quinoline | WYETH (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439364-B2 | Process for the synthesis of derivatives of halo-[2,3-F] quinoline | WYETH (US) | 2008-10-21 | — | — | US | disclosed |
| US-7419986-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| US-7335666-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-02-26 | — | — | US | disclosed |
| EP-1537122-B9 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH CORP (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1537122-B1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH CORP (US) | 2007-08-22 | — | — | EP | disclosed |
| US-20070123705-A1 | Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines | WYETH (US) | 2007-05-31 | — | — | US | disclosed |
| US-20040142926-A1 | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH | 2004-07-22 | — | — | US | disclosed |
| US-20040138222-A1 | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | WYETH | 2004-07-15 | — | — | US | disclosed |
| WO-2004024733-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024731-A1 | ANTIDEPRESSANT ARYLPIPERAZINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024734-A1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024730-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
| US-6693197-B2 | Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino- [2,3-f] quinoline | WYETH | 2004-02-17 | — | — | US | disclosed |
| EP-1387845-A2 | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE | Wyeth (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020187983-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | WYETH | 2002-12-12 | — | — | US | disclosed |
| WO-2002092602-A2 | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-[2,3-f] QUINOLINE | WYETH (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138222-A1 | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | HTR5A, TPH1, DBH | HTR1A 13/4885CYP3A4 306/4885CYP2C8 965/4885 |
| US-20070123705-A1 | Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines | CYP1A1, CYP2F1, CYP4X1 | HTR1A 468/4885CYP3A4 29/4885CYP2C8 174/4885 |
| US-20020187983-A1 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline | CYP1A1, CYP2F1, CYP1B1 | HTR1A 449/4885CYP3A4 18/4885CYP2C8 185/4885 |
| US-20040142926-A1 | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | HTR5A, CYP19A1, CRH | HTR1A 39/4885CYP3A4 186/4885CYP2C8 624/4885 |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | HTR1A 39/4885CYP3A4 445/4885CYP2C8 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.