Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732410 | 0.89 | TBXAS1 (0.40) | TBXAS1NAMPTL3MBTL1POLB | |
| SCHEMBL4734005 | 0.85 | TBXAS1 (0.39) | TBXAS1NAMPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4734428 | 0.79 | HTT (0.40) | SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4731926 | 0.77 | POLB (0.47) | TBXAS1SMN1; SMN2ALDH1A1L3MBTL1POLB | |
| SCHEMBL4731674 | 0.75 | PTGDR2 (0.33) | — | |
| SCHEMBL4731516 | 0.74 | MEN1 (0.39) | NAMPTSMN1; SMN2ALDH1A1L3MBTL1POLB | |
| SCHEMBL4619417 | 0.73 | ALPL (0.54) | TBXAS1NAMPTSMN1; SMN2ALPLALDH1A1 | |
| SCHEMBL4733638 | 0.72 | TBXAS1 (0.41) | TBXAS1NAMPTPOLB | |
| SCHEMBL4734755 | 0.72 | POLB (0.46) | TBXAS1NAMPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4730979 | 0.72 | TBXAS1 (0.42) | TBXAS1SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |