Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731516 | 0.90 | MEN1 (0.39) | ALDH1A1HTTSMN1; SMN2NAMPTPOLB | |
| SCHEMBL4732410 | 0.87 | TBXAS1 (0.40) | TBXAS1NAMPTPOLBTSHRKDM4E | |
| SCHEMBL4730979 | 0.86 | TBXAS1 (0.42) | TBXAS1ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL4734133 | 0.86 | TBXAS1 (0.40) | TBXAS1ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL4730169 | 0.85 | TBXAS1 (0.38) | TBXAS1ALDH1A1SMN1; SMN2NAMPTPOLB | |
| SCHEMBL4737048 | 0.82 | TBXAS1 (0.39) | TBXAS1ALDH1A1HTTSMN1; SMN2NAMPT | |
| SCHEMBL4731926 | 0.79 | POLB (0.47) | TBXAS1ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL4734428 | 0.78 | HTT (0.40) | ALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL4617716 | 0.76 | TBXAS1 (0.51) | TBXAS1ALDH1A1HTTSMN1; SMN2NAMPT | |
| SCHEMBL4732031 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |