Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 5/20 | 0.45 |
| ▸ | CNR2 | P34972 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734532 | 0.82 | NPC1 (0.55) | LMNARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL4782358 | 0.77 | CNR2 (0.52) | ALDH1A1CNR1CNR2PKM | |
| SCHEMBL4732719 | 0.74 | PKM (0.51) | LMNAALDH1A1GAANPSR1SMN1; SMN2 | |
| SCHEMBL4733274 | 0.73 | CNR2 (0.69) | CNR1CNR2 | |
| SCHEMBL5624844 | 0.67 | NPC1 (1.00) | RAB9ANPC1ALDH1A1GAAKDM4E | |
| SCHEMBL17749369 | 0.65 | LMNA (0.66) | LMNAALDH1A1GAAKDM4ENPSR1 | |
| SCHEMBL15834046 | 0.64 | HRH4 (0.48) | RAB9ANPC1ALDH1A1GAAKDM4E | |
| SCHEMBL17749349 | 0.63 | WNK1 (0.62) | LMNAALDH1A1GAAKDM4EHPGD | |
| SCHEMBL5253649 | 0.62 | CTSK (0.58) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL17300713 | 0.62 | HRH4 (0.45) | ALDH1A1GAAKDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | claimed |
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |