SCHEMBL473082

SCHEMBL473082

CCOC(=O)Nc1ccc(C)c(NC(=O)OCC)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 1/20 0.66
ALDH1A1 P00352 4/20 0.64
LMNA P02545 2/20 0.64
MAPK1 P28482 2/20 0.64
SMN1; SMN2 Q16637 3/20 0.61
CYP1A2 P05177 3/20 0.58
CYP2C9 P11712 3/20 0.58
CYP2C19 P33261 3/20 0.58
NPC1 O15118 4/20 0.56
RAB9A P51151 4/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
HTT P42858 1/20 0.56
HSD17B10 Q99714 2/20 0.55
MAPT P10636 1/20 0.55
POLB P06746 1/20 0.55
HPGD P15428 3/20 0.55
KDM4E B2RXH2 2/20 0.55
EGFR P00533 2/20 0.54
KDR P35968 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26887084 0.95 NLRP3 (0.61) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL11443749 0.94 NLRP3 (0.59) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL11399068 0.94 NLRP3 (0.58) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL11393542 0.94 NLRP3 (0.58) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL7563975 0.94 NLRP3 (0.58) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL14144110 0.92 NLRP3 (0.57) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL811637 0.90 NLRP3 (0.56) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL1026416 0.89 LMNA (0.61) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL11085743 0.88 SMN1; SMN2 (0.57) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2
SCHEMBL14399629 0.88 ALDH1A1 (0.70) NLRP3ALDH1A1LMNAMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105860568-A Primary treatment process of pallet produced by utilizing waste and old textiles 广德天运新技术股份有限公司 2016-08-17 CN claimed
US-8846970-B2 Metal carbamates formed from tolylenediamines BASF SE (DE) 2014-09-30 US claimed
US-20130231495-A1 METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES BASF SE (DE) 2013-09-05 US claimed
EP-2265573-B1 METAL CARBAMATES COMPOSED OF TOLYLENEDIAMINES BASF SE (DE) 2011-10-12 EP claimed
US-20110004012-A1 METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES BASF SE (DE) 2011-01-06 US claimed
US-4055629-A Process for the removal of selenium compounds from urethane solutions ATLANTIC RICHFIELD COMPANY (US) 1977-10-25 US claimed
US-4038375-A PROCESS FOR THE RECOVERY OF SELENIUM FROM SELENIUM-CONTAINING URETHANE SOLUTIONS ATLANTIC RICHFIELD COMPANY (US) 1977-07-26 US claimed
US-3993685-A Process for the production of urethanes ATLANTIC RICHFIELD COMPANY (US) 1976-11-23 US claimed
US-3962302-A Production of isocyanates from esters of carbamic acids (urethanes) ATLANTIC RICHFIELD COMPANY (US) 1976-06-08 US claimed
JP-5201953-A None JP disclosed
EP-3293173-B1 METHOD FOR PRODUCING ISOCYANATE ASAHI CHEMICAL IND (JP) 2021-07-28 EP disclosed
EP-3838892-A1 METHOD FOR PRODUCING ISOCYANATE Asahi Kasei Kabushiki Kaisha (JP) 2021-06-23 EP disclosed
EP-2980066-B1 METHOD FOR PRODUCING ISOCYANATE ASAHI CHEMICAL IND (JP) 2021-04-21 EP disclosed
US-20200225581-A1 PHOTOSENSITIVE RESIN COMPOSITION, OPTICAL FILM, AND METHOD OF PRODUCING OPTICAL FILM ECHEM SOLUTIONS CORP. (TW) 2020-07-16 US disclosed
US-4219661-A FROM THE NITRO COMPOUND BAYER AKTIENGESELLSCHAFT (DE) 1980-08-26 US disclosed
EP-0014406-A1 Process for the separation of selenium, selenium compounds, sulfur and/or sulfur compounds from urethanes containing these elements and/or compounds BAYER AG (DE) 1980-08-20 EP disclosed
EP-0014406-A1 Process for the separation of selenium, selenium compounds, sulfur and/or sulfur compounds from urethanes containing these elements and/or compounds BAYER AG (DE) 1980-08-20 EP disclosed
US-4081472-A CATALYTIC, FROM A CARBAMATE MITSUI TOATSU CHEMICALS INC. (JA) 1978-03-28 US disclosed
US-3993685-A Process for the production of urethanes ATLANTIC RICHFIELD COMPANY (US) 1976-11-23 US disclosed
US-3962302-A Production of isocyanates from esters of carbamic acids (urethanes) ATLANTIC RICHFIELD COMPANY (US) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130231495-A1 METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES CHRM1, CARM1, TCP1 NLRP3 4276/4885ALDH1A1 1601/4885LMNA 4197/4885
US-20110004012-A1 METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES CHRM1, CARM1, TCP1 NLRP3 4276/4885ALDH1A1 1601/4885LMNA 4197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.