Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733867 | 0.89 | MEN1 (0.46) | KMT2AMEN1PDE4BPDE4CPDE4D | |
| SCHEMBL4734755 | 0.83 | POLB (0.46) | KMT2AMEN1PDE4BPDE4CPDE4D | |
| SCHEMBL4731333 | 0.80 | PRMT5 (0.46) | KMT2AMEN1RAB9AMAPTALDH1A1 | |
| SCHEMBL4781177 | 0.80 | KMT2A (0.49) | KMT2APOLBTP53MAPTLMNA | |
| SCHEMBL4732610 | 0.78 | NR2F2 (0.51) | POLBRAB9AMAPTLMNAL3MBTL1 | |
| SCHEMBL4733368 | 0.77 | CHRM2 (0.41) | KMT2AMEN1MAPT | |
| SCHEMBL4734091 | 0.77 | MAOA (0.33) | — | |
| SCHEMBL4730919 | 0.76 | POLB (0.58) | KMT2AMEN1POLBPKML3MBTL1 | |
| SCHEMBL4732276 | 0.75 | CNR2 (0.41) | KMT2AMEN1TP53MAPT | |
| SCHEMBL4732203 | 0.75 | CYP19A1 (0.59) | KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |