Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732610 | 0.90 | NR2F2 (0.51) | HTTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL4734755 | 0.89 | POLB (0.46) | MEN1KMT2AHTTPKMALDH1A1 | |
| SCHEMBL4734747 | 0.89 | KMT2A (0.48) | MEN1KMT2APKMALDH1A1LMNA | |
| SCHEMBL4731333 | 0.84 | PRMT5 (0.46) | MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL4730919 | 0.81 | POLB (0.58) | MEN1KMT2AHTTPKMALDH1A1 | |
| SCHEMBL4732203 | 0.80 | CYP19A1 (0.59) | KMT2AALDH1A1LMNA | |
| SCHEMBL4781177 | 0.80 | KMT2A (0.49) | KMT2AALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL4734768 | 0.78 | MEN1 (0.57) | MEN1KMT2AALDH1A1POLB | |
| SCHEMBL4733368 | 0.77 | CHRM2 (0.41) | MEN1KMT2A | |
| SCHEMBL4732276 | 0.75 | CNR2 (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |