Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 5/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780748 | 0.76 | CCR2 (0.41) | TACR1TSHRCYP3A4 | |
| SCHEMBL4730933 | 0.76 | TACR1 (0.40) | ALDH1A1SMN1; SMN2NPSR1TACR1UBE2M | |
| SCHEMBL3996741 | 0.70 | PARP1 (0.41) | — | |
| SCHEMBL4000751 | 0.69 | TACR1 (0.36) | TACR1MAPTUBE2MDCUN1D1TSHR | |
| SCHEMBL4730592 | 0.69 | TACR1 (0.35) | SMN1; SMN2TACR1MAPTCYP3A4 | |
| SCHEMBL14221691 | 0.68 | TACR1 (0.65) | ALDH1A1TACR1TSHRHTTCYP3A4 | |
| SCHEMBL4731307 | 0.68 | CETP (0.44) | TACR1 | |
| SCHEMBL3029505 | 0.68 | TACR1 (0.51) | ALDH1A1SMN1; SMN2TACR1MAPTTSHR | |
| Ammonia Solution, Strong SCHEMBL3036646 | 0.67 | TACR1 (0.64) | ALDH1A1TACR1TSHRHTTCYP3A4 | |
| SCHEMBL4732423 | 0.67 | CETP (0.41) | TACR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | disclosed |