Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16453663 | 0.86 | L3MBTL1 (0.58) | NPC1TSHRL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL12113209 | 0.84 | NPC1 (0.61) | NPC1TSHRL3MBTL1MAPK1GAA | |
| SCHEMBL123523 | 0.84 | L3MBTL1 (0.64) | NPC1TSHRL3MBTL1MAPK1GAA | |
| SCHEMBL9428921 | 0.84 | LMNA (0.50) | NPC1TSHRL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL17063917 | 0.83 | NPC1 (0.64) | NPC1TSHRL3MBTL1GAAALDH1A1 | |
| SCHEMBL4724490 | 0.83 | L3MBTL1 (0.58) | NPC1TSHRL3MBTL1MAPK1GAA | |
| SCHEMBL5227668 | 0.83 | ALDH1A1 (0.44) | NPC1TSHRL3MBTL1MAPK1GAA | |
| SCHEMBL6609846 | 0.82 | TDP1 (0.47) | NPC1TSHRL3MBTL1MAPK1GAA | |
| SCHEMBL1313733 | 0.81 | L3MBTL1 (0.74) | NPC1L3MBTL1MAPK1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3898462 | 0.81 | TDP1 (0.46) | NPC1TSHRL3MBTL1MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481574-B2 | (2Z)-2-(3-butyl-4,5-dimethyl-1,3-thiazol-2(3H)-ylidene)-1-(5-chloro-2-methoxyphenyl)ethanone; antiinflammatory, analgesic agent; autoimmune diseases; neuroprotectants | ABBOTT LABORATORIES (US) | 2013-07-09 | — | — | US | disclosed |
| US-20080255123-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008063781-A2 | CHEMICAL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2008-05-29 | — | — | WO | disclosed |
| US-3992388-A | INTERMEDIATE FOR SULFAMYLUREA HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3987172-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1976-10-19 | — | — | US | disclosed |
| US-3944524-A | ORAL HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1976-03-16 | — | — | US | disclosed |
| US-3933830-A | FROM 4-(2-PYRIDYLAMIDOETHYL) PYRIDINES REDUCED WITH HYDROGEN AND A NOBLE METAL CATALYST | PFIZER INC. (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255123-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | CNR1, CNR2, GPR18 | NPC1 558/4885TSHR 497/4885L3MBTL1 2413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.