Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.32 |
| ▸ | FEN1 | P39748 | 3/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731297 | 0.94 | TP53 (0.34) | KDM4ENPSR1IKBKBMAPTMAPK1 | |
| SCHEMBL4732780 | 0.93 | NTRK1 (0.34) | NTRK1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL4730446 | 0.90 | KDM4E (0.38) | KDM4ENPSR1IKBKBMAPTPOLB | |
| SCHEMBL4731314 | 0.86 | APOBEC3A (0.33) | ALDH1A1 | |
| SCHEMBL4731338 | 0.85 | IRAK4 (0.35) | MAPT | |
| SCHEMBL4727903 | 0.84 | MAPT (0.39) | KDM4ENPSR1MAPT | |
| SCHEMBL4732282 | 0.84 | KDM4E (0.32) | KDM4ENPSR1IKBKBMAPTALDH1A1 | |
| SCHEMBL4730991 | 0.82 | APOBEC3A (0.33) | NTRK1KDM4EHPGD | |
| SCHEMBL4139806 | 0.79 | KDM4E (0.36) | KDM4EIKBKBHPGDSYK | |
| SCHEMBL4139800 | 0.79 | KDM4E (0.36) | KDM4EIKBKBHPGDSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |